Clustering antipsychotics based on their receptor affinity
Since I did the same analysis for antidepressants yesterday, I figured that I would analyze the receptor binding profiles of antipsychotics today. Here is a visualization:
And here is a dendrogram based on a clustering of those receptor affinities:
It turns out that it's much harder to see a trend in which these classes cluster based on chemical structure like the antidepressants did, but perhaps you will be able to notice some trends:
Group #1: Benzamides like sulpride (not approved in the US)
Group #2: Phenothiazines like perphenazine, fluphenazine, chlorpromazine, and the structurally similar thioxanthene; the diphenylbutylpiperidine pimozide; the butyrophenone haloperidol; and the piperidine thioridazine the; dibenzothiazepine quetiapine; and the phenylpiperazine aripiprazole
Group #3: The dibenzoxazepine loxapine, structurally related to the dibenzodiazepines clozapine; another dibenzothiapine, zotepine; and and thienobenzodiazepines like olanzapine
Group #4: The dibenzooxepinopyrrole asenapine
Group #5: The azaspirodecanediones like risperidone, its active metabolite paliperidone; and the benzothiazolyl piperazine aripiprazole
Here's my code to reproduce this.